Improved Cordycepin Production by Cordyceps militaris KYL05 Using Casein Hydrolysate in Submerged Conditions
نویسندگان
چکیده
منابع مشابه
Production of cordycepin by Cordyceps militaris using submerged liquid culture: Optimization of the culture medium and repeated batch fermentation
Cordycepin (3’-deoxyadenosine) is one of the most versatile metabolites of Cordyceps militaris due to its broad spectrum of biological activity. In this study, response surface methodology (RSM) was applied to optimize the medium components for the cordycepin production by submerged liquid culture. The optimal parameters for cordycepin production within the experimental range of the variables r...
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Performance of Cordyceps militaris mutant obtained by high-energy ion beam irradiation regarding anti-cancer agent cordycepin production in submerged culture was investigated. It was established that the mutant renders a higher production performance in surface liquid culture, needs to observe its performance in submerged culture. Two kinds of media were used for submerged culture comprising a ...
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Cordycepin is one of the most important bioactive compounds produced by species of Cordyceps sensu lato, but it is hard to produce large amounts of this substance in industrial production. In this work, single factor design, Plackett-Burman design, and central composite design were employed to establish the key factors and identify optimal culture conditions which improved cordycepin production...
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Cordycepin (3′-deoxyadenosine) exhibits antimicrobial, anticancer, antimetastatic, immunomodulatory and insecticidal effects, and is one of the most important bioactive anticancer agents found in Cordyceps species (summer grass-winter worm). However, due to the requirements of specific hosts and strict growth environments, Cordyceps militaris is very scarce in nature. Therefore, the production ...
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Cordyceps militaris, known as Dong-Chong-Xia-Cao, produces the most cordycepin among Cordyceps species and can be cultured artificially. For these reasons, C. militaris is widely used as herb or functional food in the East Asia. In this study, we developed a new strain of C. militaris that produces higher cordycepin content than parent strains through mating-based sexual reproduction. Twenty pa...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2019
ISSN: 2218-273X
DOI: 10.3390/biom9090461